Rush Oral Immunotherapy Does Not Reduce Allergic Response in Mice with Mild Allergy to Egg White Ovomucoid
نویسندگان
چکیده
منابع مشابه
Rush Oral Immunotherapy Does Not Reduce Allergic Response in Mice with Mild Allergy to Egg White Ovomucoid.
Oral immunotherapy (OIT) is a promising therapeutic approach for treating food allergy. Past studies have shown that OIT reduces allergic response only in severe allergy model mice. We worked to establish mild allergy model mice, and investigated whether 'rush' OIT for 10 d improved the allergic response and biomarkers in these mice. Balb/c mice were sensitized to ovomucoid (OM) in alum. The ru...
متن کاملCharacterization of T-cell clones specific to ovomucoid from patients with egg-white allergy.
BACKGROUND Allergic reactions to foods are specific problems for infants and young children. Ovomucoid (OM) is one of the major allergens found in egg-white. We previously established several T-cell clones (TCCs) specific to OM in non-polarizing conditions from 4 patients (TM and YN are immediate-type, IH and YT are non-immediate-type) with egg-white allergy. We characterized their reactive epi...
متن کاملOral Rush Desensitization to Egg: Efficacy
hours of cow’s milk ingestion, skin prick tests $3 mm, and serum specific IgE levels $0.35 kU/L for whole cow’s milk, casein, a-lactalbumin, or b-lactoglobulin. Persistence of CMP allergy in the 4 weeks before tolerance induction was based on positive skin and serum testing and a positive double-blind placebo-controlled food challenge to cow’s milk. Exclusion criteria included anaphylactic shoc...
متن کاملHome-based oral immunotherapy protocol with pasteurized egg for children allergic to hen's egg.
BACKGROUND In the last decade the use of different types of oral immunotherapy for food-allergic patients has increased with generally satisfactory outcomes. Cow's milk and hen's egg, a common element in the daily diet, have received the main interest. Most of these immunotherapy regimens are performed in the hospital, causing inconvenience for both children and their parents. OBJECTIVES To a...
متن کاملOral immunotherapy for treatment of egg allergy in children.
BACKGROUND For egg allergy, dietary avoidance is the only currently approved treatment. We evaluated oral immunotherapy using egg-white powder for the treatment of children with egg allergy. METHODS In this double-blind, randomized, placebo-controlled study, 55 children, 5 to 11 years of age, with egg allergy received oral immunotherapy (40 children) or placebo (15). Initial dose-escalation, ...
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ژورنال
عنوان ژورنال: Journal of Nutritional Science and Vitaminology
سال: 2015
ISSN: 0301-4800,1881-7742
DOI: 10.3177/jnsv.61.400